Upright, the Tower is strongly associated with catastrophic end. It is a card of sudden and unexpected shock, chaos, and disruption.
A card of such universal devastation means that, when you reverse it, it’s hard to narrow down the meaning to a few quick notions, but here you go:

1. Avoidance of disaster
2. A very personal transformation or tragedy
3. The fear of change or catastrophe
4. An oppression or inability to break free

 
{6.21.21 note: At this current time in my life I am paralyzed by a severe fear of catastrophe, so I'm excited to read on and see what I should do about it...}

Questions answered by The Tower Reversed:
Who? A difficult person; one who has recently suffered a catastrophe 
What? Cleanup after a storm or emergency
Where? A volatile location; an area after a storm
When? March to April, October to November; After the tragedy
Why? “Times of crisis, of disruption or constructive change, are not only predictable, but desirable. They mean growth. Taking a new step, uttering a new word, is what people fear most.” - Fyodor Dostoevsky
Yes or No? No

What should I clean?

• Prepare or replenish emergency supplies
• Throw out 16 dangerous pieces of clutter

 
Where are my keys?

• Near a fire hazard or dangerous item

 
The Tower Reversed as:
…an action?

• Visit a therapist for grief or recovery
• Take a long, hot bath to relax
• Cry it out

…a place in your house?

• The peephole
• The window in the front door

• The tub
• The liquor cabinet

…a place in your city?

• A recently dismantled building
• A place with "Tower" in the title
• A rehab, recovery, or grief counseling location

  
…a place in the world?

• New Zealand
• The Caribbean
• A global humanitarian aid foundation

 
…something to eat?

• Canned goods
• Granola or trail mix
• Peanut butter

 
…a color? Electric blue
 
…movie theme? Disaster recovery; fear of ruin

• Bird Box

• Thor: Ragnarok
• Fatherhood

…a new career?

• Disaster recovery
• Nonprofit humanitarian work
• Grief counseling or psychotherapy

Possible Major Arcana combinations with The Tower Reversed:
Upright Fool: Keep an eye on the kids
Reversed Magician: Fear of job loss
Upright Priestess: Personal trouble; emotions
Reversed Empress: A worried mother or parent
Upright Emperor: A struggling business
Reversed Hierophant: A falling out; lost faith
Upright Lovers: Avoiding a breakup; no divorce
Reversed Chariot: Fear of flight; travel delayed
Upright Strength: Training for emergencies
Reversed Hermit: Lack of adequate preparation
Upright Wheel: Disaster avoided this time
Reversed Justice: White collar crime
Upright Hanged One: decisions must be made to avoid disaster, don’t delay
Reversed Death: Unnecessary fear
Upright Temperance: Everything is in balance
Reversed Devil: Smooth sailing; all disasters are averted
Upright Star: Foretells recovery from disaster
Reversed Moon: A difficult journey to recovery
Upright Sun: After a big change there is bliss
Reversed Judgement: Extreme self doubt
Upright World: A personal transformation
 
Before any card: Recovery from a disaster related to (card theme)
After any card: Disaster recovery
 
The Major Arcana represent significant life events. The Tower Reversed could indicate:

• Post-disaster
• Cleanup after a natural catastrophe
• Fear
• Reconciliation

{6.21.21 note: I watched a sappy movie so I had a good cry this morning. I do feel better! Thanks Tower Reversed!}

It's September 23rd, 2020, and the situation around the globe is scary, frenetic, and unpredictable. What a great time for the Tower card! It is a card of sudden and unexpected shock, chaos, and disruption.

Questions answered by The Tower:
Who? The one who controls your fate - such as a boss; 
What? Emergency preparations, imminent disaster
Where? A place where disaster has struck
When? March to April, October to November; Immediate and surprising
Why? Tragedy is inevitable
Yes or No? No
 
What should I clean?

• The worst mess
• The mess you've been trying to avoid

 
Where are my keys?

• You dropped them somewhere terrible, such as down a grate or into mud

Ask yourself this - in the worst of times, will you run away out of fear, or will you face the devastation with purpose? There is no wrong answer, as the fight vs flight reaction is a biological necessity designed for your safety. If running protects you, run. If fighting empowers you, fight. 
Whatever your move, resist apathy, or you'll backtrack into the previous card in the Major Arcana--the Devil. Idle hands are the devil's playground, after all. 
​
When the Tower appears, do something.